Kazunori D Yamada, PhD

Affiliation

東北大学・未踏スケールデータアナリティクスセンター・教授

Professor, Unprecedented-scale Data Analytics Center, Tohoku University

東北大学・情報科学研究科（兼務）

Graduate School of Information Sciences, Tohoku University

産業技術総合研究所・人工知能研究センター・客員研究員

Visiting Researcher, Artificial Intelligence Research Center, AIST

Research Interests

人工知能と意識 / 文脈情報処理のためのニューラルネットワークと対話エージェント / テレビゲームとエンターテイメント

Strong AI and machine consciousness / neural network for sequence processing and dialogue agent / video game and entertainment

Collaboration

研究内容が縛られるため予算獲得も共同研究もしたくないと普段から言っているのにも関わらず，あまりにも多いので明記しますが「何の興味もない研究ドメインにて深層学習モデル作ってください」みたいな，やってるこっちが何も面白くない「共同研究」という名のだたの下働きのお誘い，そんなことに費やす時間はないのでぜひご遠慮下さい．ご自身に置き換えて想像してみてください．「あなたと共同研究したいです．エクセル使ってひたすら足し算してくれますか？」みたいな共同研究したいですか？

深層学習を含むデータ科学はアカデミアにおいてはコモディティ化しつつあります．情報科学の研究者が共同研究者からデータを預かってデータ科学を適用することが良しとされたフェーズはずっと前に終わっています．ぜひ各研究ドメインでデータ科学を使ってください．現時点で使えないなら相談や教育は引き受けます．アカデミアの情報科学の研究者にはもっと別の役割があることをご理解ください（いやホントマジでそろそろ理解してください）．

所属組織としての共同研究は当然しますし，これまでにご一緒させていただいている共同研究者の方とはやります．2023年4月以降，それ以外で何の興味もない研究ドメインからのお誘いはお断りします．現時点で興味があるドメインは「汎用人工知能とか強い人工知能の実現」とか「機械学習法の高度化」とか「人工意識の実現」とか「ゲーム人工知能の高度化」とかのみで，この分野での協働は歓迎します．

Research Achievements

Refereed Journal Papers

1. Nagase Y, Satoh T, Shigetome K, Tokumaru N, Matsumoto E, Yamada KD, Imafuku T, Watanabe H, Maruyama T Ogata Y Yoshida M, Saruwatari J, Oniki K, Serum fatty acid composition balance by fuzzy c-means method in individuals with or without metabolic dysfunction-associated fatty liver disease, Nutrients, 15(4):809, 2023
2. Yamada KD, Baladram MS, Lin F, Relation is an option for processing context information, Frontiers in Artificial Intelligence, 5:924688, 2022
3. Yasukawa K, Yamada K, Tokuda H, Koyama S, Utsumi H, Redox imaging of dextran sodium sulfate-induced colitis mice treated with nitric oxide synthase inhibitors, Advances in Redox Research, 6, 2022
4. Lin F, Xu Y, Zhang Z, Gao C, Yamada KD, Cosmos Propagation Network: Deep learning model for point cloud completion, Neurocomputing, 507:221-234, 2022
5. Yamada KD, Baladram MS, Lin F, Progress in research on implementing machine consciousness, Interdisciplinary Information Sciences, 28(1):95-105, 2022
6. Lin F, Gao C, Yamada KD, An effective convolutional neural network for visualized understanding transboundary air pollution based on Himawari-8 satellite images, IEEE Geoscience and Remote Sensing Letters, 19:1-5, 2022
7. Yamada KD, Lin F, Nakamura T, Developing a novel recurrent neural network architecture with fewer parameters and good learning performance, Interdisciplinary Information Sciences, 27(1):25-40, 2021
8. Baladram MS, Koike A, Yamada KD, Introduction to supervised machine learning for data science, Interdisciplinary Information Sciences, 26(1):87-121, 2020
9. Katoh K, Rozewicki J, Yamada KD, MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization, Briefings in Bioinformatics, 20(4):1160-1166, 2019
10. Yasukawa K, Hirago A, Yamada K, Tun X, Ohkuma K, Utsumi H, In vivo redox imaging of dextran sodium sulfate-induced colitis in mice using Overhauser-enhanced magnetic resonance imaging, Free Radical Biology and Medicine, 136:1-11, 2019
11. Yamada KD, Kinoshita K, De novo profile generation based on sequence context specificity with the long short-term memory network, BMC Bioinformatics, 19(1):272, 2018
12. Nakamura T, Yamada KD, Tomii K, Katoh K, Parallelization of MAFFT for large-scale multiple sequence alignments, Bioinformatics, 34(14):2490-2492, 2018
13. Yamada KD, Derivative-free neural network for optimizing the scoring functions associated with dynamic programming of pairwise-profile alignment, Algorithms for Molecular Biology, 13:5, 2018
14. Yamada KD, Kunishima N, Matsuura Y, Nakai K, Naitow H, Fukasawa Y, Tomii K, Designing better diffracting crystals of biotin carboxyl carrier protein from Pyrococcus horikoshii by a mutation based on crystal-packing propensity of amino acids, Acta Crystallographica Section D, 73(9):757-766, 2017
15. Yamada KD, Omori S, Nish H, Miyagi M, Identification of the sequence determinants of protein N-terminal acetylation through a decision tree approach, BMC Bioinformatics, 18(1):289, 2017
16. Lim K, Yamada KD, Frith MC, Tomii K, Protein sequence-similarity search acceleration using a heuristic algorithm with a sensitive matrix, Journal of Structural and Functional Genomics, 17(4):147-154, 2016
17. Yamada KD, Tomii K, Katoh K, Application of the MAFFT sequence alignment program to large data - reexamination of the usefulness of chained guide trees, Bioinformatics, 32(21):3246-3251, 2016
18. Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H, Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro-in vivo-integrated screens of chemical libraries, Scientific Reports, 6:33861, 2016
19. Lensink MF, Velankar S, Kryshtafovych A, Huang SY, Schneidman-Duhovny D, Sali A, Segura J, Fernandez-Fuentes N, Viswanath S, Elber R, Grudinin S, Popov P, Neveu E, Lee H, Baek M, Park S, Heo L, Rie Lee G, Seok C, Qin S, Zhou HX, Ritchie DW, Maigret B, Devignes MD, Ghoorah A, Torchala M, Chaleil RA, Bates PA, Ben-Zeev E, Eisenstein M, Negi SS, Weng Z, Vreven T, Pierce BG, Borrman TM, Yu J, Ochsenbein F, Guerois R, Vangone A, Rodrigues JP, van Zundert G, Nellen M, Xue L, Karaca E, Melquiond AS, Visscher K, Kastritis PL, Bonvin AM, Xu X, Qiu L, Yan C, Li J, Ma Z, Cheng J, Zou X, Shen Y, Peterson LX, Kim HR, Roy A, Han X, Esquivel-Rodriguez J, Kihara D, Yu X, Bruce NJ, Fuller JC, Wade RC, Anishchenko I, Kundrotas PJ, Vakser IA, Imai K, Yamada K, Oda T, Nakamura T, Tomii K, Pallara C, Romero-Durana M, Jiménez-García B, Moal IH, Férnandez-Recio J, Joung JY, Kim JY, Joo K, Lee J, Kozakov D, Vajda S, Mottarella S, Hall DR, Beglov D, Mamonov A, Xia B, Bohnuud T, Del Carpio CA, Ichiishi E, Marze N, Kuroda D, Roy Burman SS, Gray JJ, Chermak E, Cavallo L, Oliva R, Tovchigrechko A, Wodak SJ, Prediction of homoprotein and heteroprotein complexes by protein docking and template‐based modeling: A CASP‐CAPRI experiment, Proteins, 84(S1):323-348, 2016
20. Kakisaka M, Yamada K, Yamaji-Hasegawa A, Kobayashi T, Aida Y, Intrinsically disordered region of influenza A NP regulates viral genome packaging via interactions with viral RNA and host PI(4,5)P2, Virology, 496:116-126, 2016
21. Yamada KD, Nishi H, Nakata J, Kinoshita K, Structural characterization of single nucleotide variants at ligand binding sites and enzyme active sites of human proteins, Biophysics and Physicobiology, 13:157-163, 2016
22. Tomii K, Yamada K, Systematic exploration of an efficient amino acid substitution matrix: MIQS, Methods in Molecular Biology, 1415:211-223, 2016
23. Polat M, Takeshima SN, Hosomichi K, Kim J, Miyasaka T, Yamada K, Arainga M, Murakami T, Matsumoto Y, de la Barra Diaz V, Panei CJ, González ET, Kanemaki M, Onuma M, Giovambattista G, Aida Y, A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis, Retrovirology, 13(1):4, 2016
24. Kakisaka M, Sasaki Y, Yamada K, Kondoh Y, Hikono H, Osada H, Tomii K, Saito T, Aida Y, A novel antiviral target structure involved in the RNA binding, dimerization, and nuclear export functions of the influenza A virus nucleoprotein, PLOS Pathogens, 11(7):e1005062, 2015
25. Ito JI, Ikeda K, Yamada K, Mizuguchi K, Tomii K, PoSSuM v.2.0: data update and a new function for investigating ligand analogs and target proteins of small-molecule drugs, Nucleic Acids Research, 43(D1):D392-D398, 2015
26. 山田和範, 富井健太郎, 遠縁タンパク質検索に適した新規アミノ酸置換行列, 生物物理, 55(3):133-136, 2015
27. Chutiwitoonchai N, Kakisaka M, Yamada K, Aida Y, Comparative analysis of seven viral nuclear export signals (NESs) reveals the crucial role of nuclear export mediated by the third NES consensus sequence of nucleoprotein (NP) in influenza A virus replication, PLOS ONE, 9(8):e105081, 2014
28. Yamada K, Tomii K, Revisiting amino acid substitution matrices for identifying distantly related proteins, Bioinformatics, 30(3):317-325, 2014
29. Sasaki Y, Hagiwara K, Kakisaka M, Yamada K, Murakami T, Aida Y, Importin α3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function, PLOS ONE, 8(1):e55765, 2013
30. Yamada K, Koyama H, Hagiwara K, Ueda A, Sasaki Y, Kanesashi SN, Ueno R, Nakamura HK, Kuwata K, Shimizu K, Suzuki M, Aida Y, Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase, Microbes and Infection, 14(9):740-747, 2012
31. Hagiwara K, Kondoh Y, Ueda A, Yamada K, Goto H, Watanabe T, Nakata T, Osada H, Aida Y, Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays, Biochemical and Biophysical Research Communications, 394:721-727, 2010

Preprint Entries

32. Yamada KD, Baladram MS, Lin F, Relation is an option for processing context information, bioRxiv, 2022.04.14.488336, 2022
33. Yan Z, Omori S, Yamada KD, Nishi H, Kinoshita K, Prediction and characterization of disorder-order transition regions in proteins by deep learning, bioRxiv, 2021.06.11.448022, 2021
34. Yamada KD, Lin F, Nakamura T, Developing a novel recurrent neural network architecture with fewer parameters and good learning performance, bioRxiv, 2020.04.08.031484, 2020
35. Yamada KD, Hyperparameter-free optimizer of gradient-descent method incorporating unit correction and moment estimation, bioRxiv, 348557, 2018
36. Yamada KD, Kinoshita K, De novo profile generation based on sequence context specificity with the long short-term memory network, bioRxiv, 240515, 2018
37. Yamada KD, Optimizing scoring function of dynamic programming of pairwise profile alignment using derivative free neural network, bioRxiv, 182493, 2018

Awards & Honors

1. Research Award, Yamada KD, Kinoshita K, Development of de novo generator of amino acid sequence profile using LSTM framework, IIBMP2017, 2017
2. Excellent Poster Award, Yamada K, Tomii K, Development of a novel amino acid substitution matrix for remote homology detection, IIBMP2013, 2013
3. Poster Award, Yamada K, Tomii K, Developing a novel amino acid substitution matrix suitable for detecting distantly related proteins, BiWO2013, 2013

Research Product

Relation	Algorithm to process context information of sequential data with good time complexity.
YamRNN	Recurrent neural network with good space complexity.
SPBuild	De novo profile generator based on recurrent neural network.
NT-AcPredictor	N-terminal acetylation predictor based on decision tree classification.
Nepal	PSSM-PSSM pairwise aligner with neural network enhanced scoring function of dynamic programming.
MAFFT-sparsecore	Benchmark results of MAFFT-sparasecore and other methods on large scale dataset.

Classes

Professional Memberships

• 日本メディカルAI学会

Grants

• 人工知能で目指すアミノ酸配列類似性検索法の高速化および高感度化研究，科研費・若手研究 (2018 - 2020)，研究課題番号：18K18143，(代表)
• MAFFT多重アラインメントプログラムの大量配列データへの対応と機能拡張，科研費・基盤研究C (2016 - 2020)，研究課題番号：16K07464，(分担)

Contact

Email: y[a-z]ma[a-z]a@tohoku.ac.jp

ハンター試験なのですがメールアドレスの2個の[a-z]はそれぞれ英語アルファベットの内の互いに異なる小文字1個です．